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In vitro reports, 25C-NBOMe has become revealed to exhibit cytotoxicity on neuronal cell traces SH-SY5Y, PC12, and SN471, and the compound was more potent than methamphetamine at lowering the visibility of the respective cells; the neurotoxicity of your compound includes activation of MAPK/ERK cascade and inhibition of Akt/PKB signaling pathway.. 2